Head-to-head comparison · 2026 Singapore prices

Juvelook vs Profhilo

/ˈdʒuːvəlʊk/ vs /prɒˈfiːloʊ/ A PDLLA collagen-stimulating booster compared with a high-dose hyaluronic acid booster for the face

Dr Joy Koh, Editor-in-ChiefWritten by Dr Joy Koh, MBBS, Editor-in-Chief · Updated

Independent review: evidence graded A to D, 2026 Singapore prices from published clinic lists, sources listed at the end of the page.

Juvelook vs Profhilo: under-eye skin booster comparison of ingredients, evidence grade and 2026 Singapore price

Overview

Juvelook and Profhilo act through different mechanisms. Juvelook combines poly-D,L-lactic acid (PDLLA) microspheres with a small amount of hyaluronic acid (HA), and the particles stimulate new collagen over 2 to 3 months, thickening the skin and adding slight volume. Profhilo is a high dose of HA, 64 mg in 2 ml, that spreads through the tissue to hydrate it. It is injected at five points on each side of the face, none of them around the eye. Under the eyes, Juvelook is supported by small studies (Grade C), including a Singapore-led study of 15 women, whereas Profhilo has no under-eye study (Grade D). Juvelook carries a small risk of nodules under the thin lower-lid skin, whereas the main side effect of Profhilo is brief swelling. In Singapore in 2026, Juvelook costs S$388 for a half vial or S$688 for a full vial per session, over three monthly sessions, and Profhilo costs S$700 to 1,500 a syringe over two sessions a month apart. Juvelook is the better-supported option for thin skin or a mild hollow under the eyes, whereas Profhilo is designed for hydration across the cheeks and jaw.

  • Juvelook stimulates collagen with PDLLA particles, whereas Profhilo hydrates with high-dose hyaluronic acid
  • Under-eye evidence Grade C for Juvelook and Grade D for Profhilo
  • Juvelook adds slight volume, whereas Profhilo adds none
  • Juvelook S$388 to 688 a vial over 3 sessions, Profhilo S$700 to 1,500 a syringe over 2 sessions
  • Juvelook carries a small nodule risk under the eyes, whereas Profhilo mainly causes brief swelling
  • No study has compared Juvelook with Profhilo
Introduction

Juvelook and Profhilo are both marketed in Singapore as skin boosters for thin, dull skin, and clinics often present them as interchangeable alternatives. The two products differ in composition, duration of effect and the strength of their evidence around the eyes. This page compares their contents, study results, risks and 2026 prices.

Juvelook vs Profhilo at a glance

Juvelook Profhilo
What it is 42.5 mg PDLLA microspheres with 7.5 mg non-cross-linked HA, mixed with saline before use 32 mg high- plus 32 mg low-molecular-weight HA in 2 ml, stabilised by heat without a chemical cross-linker
How it works PDLLA particles stimulate new collagen as they are absorbed HA spreads, binds water and is proposed to stimulate collagen and elastin
Main effect Thicker skin, slight volume Hydration, smoother texture, mild laxity
Designed for Face, including under the eyes in clinic practice Face (five points per side), neck and body
Evidence grade, under-eye C D
2026 Singapore price S$388 half vial, S$688 full vial (up to S$1,200 a session) S$700 to 1,500 per 2 ml syringe
Usual course 3 sessions, 4 weeks apart, then every 6 months 2 sessions, 4 weeks apart, then every 6 months
Downtime Swelling for 2 to 3 days Bumps at the injection points for 1 to 3 days
Longest published follow-up 6 months Up to about 6 months (face)
Main risks Nodules if placed too superficially, rare vascular blockage Swelling, redness, bruising
Singapore registration (Health Sciences Authority) Listed to fill skin depressions and restore soft-tissue volume “Treatment of the face”

How Juvelook and Profhilo work, collagen stimulation vs hydration

  • Juvelook Porous PDLLA microspheres trigger a controlled inflammatory response in which fibroblasts, the collagen-producing cells of the dermis, deposit new collagen around each particle as it is gradually absorbed over months. The small amount of HA provides immediate hydration. The result builds over 2 to 3 months and adds slight volume as well as thickness. Juvelook Volume (Lenisna) is a stronger formulation intended for deeper volume and is not the version usually used under the eyes.
  • Profhilo Long and short HA chains are heated together to form stable complexes without a chemical cross-linker, which leaves the gel fluid enough to spread from each injection point rather than remaining as a discrete deposit. Profhilo hydrates the skin and, in laboratory studies, stimulates collagen and elastin production, although the principal laboratory paper now carries an expression of concern from its journal. Because the gel spreads thinly through the tissue, it adds no volume. Profhilo Structura is a separate, thicker product designed for the outer cheek.

Juvelook vs Profhilo under the eyes

  • Juvelook, Grade C In a Singapore-led prospective study of 15 women, three monthly sessions of about 0.4 ml per eye improved tear-trough appearance and lower-lid elasticity, hydration and radiance. The study had no control group, and both authors have received speaker fees from the manufacturer. A small Korean case series reported improvement maintained at 6 months.
  • Profhilo, Grade D No study has tested Profhilo under the eyes. Its five standard injection points lie over the cheekbone, beside the nostril, in front of the ear, at the marionette line and at the angle of the jaw, and its Singapore registration covers “treatment of the face” without naming the eye area. In a report of three patients treated on the upper third of the face, lower-lid swelling developed and settled within a week. The swelling likely reflects the spread of a fluid, water-binding gel into the loose tissue of the lower lid.
  • Juvelook vs Profhilo head to head, Grade D No study has compared the two products. The difference between Grade C and Grade D therefore reflects the existence of under-eye data for Juvelook, not a demonstrated superiority in result.

For a deeper tear-trough groove, hyaluronic acid filler has much stronger evidence than either booster. Filler options are compared on the Sunken eyes treatment in Singapore page.

Juvelook vs Profhilo for the face and skin quality

  • Profhilo on the face In an open-label study of 64 women, wrinkle and volume-loss scores improved after two sessions and remained better at 16 weeks. A Singapore study of 30 Chinese women, with manufacturer co-authors, found improved hydration at 12 weeks. Two small randomised trials were less favourable. Around the mouth, the gain in skin thickness did not exceed that produced by a saline placebo, and on the forehead, adding Profhilo to Botox produced no additional benefit. The favourable results therefore come from uncontrolled studies, whereas both controlled trials found no benefit over the comparator.
  • Juvelook on the face In a randomised split-face trial of 33 patients, Juvelook Volume performed as well as poly-L-lactic acid (Sculptra) for nasolabial folds at 24 weeks. In a study of 16 patients, skin biopsies taken after 2 to 3 sessions showed increased dermal collagen and elastic fibres, which provides tissue evidence of the collagen-stimulating mechanism.

Juvelook vs Profhilo price in Singapore (2026)

Product Per session Usual course Course total
Juvelook S$388 half vial, S$688 full vial (up to S$1,200) 3 sessions S$1,200 to 3,600
Profhilo S$700 to 1,500 per 2 ml syringe 2 sessions S$1,400 to 3,000

Some Singapore clinics list Juvelook only as a “PDLLA skin booster” and Profhilo as a “5-point HA skin booster” or “HA 5-point lift”. A quote is comparable only when it names the product and the volume injected, because other PDLLA and HA boosters differ in composition and concentration.

Juvelook vs Profhilo side effects

  • Juvelook Swelling lasts 2 to 3 days, and bruising occurs occasionally. The specific risk under the eyes is nodules, firm lumps that can appear weeks after treatment when particles sit too close to the thin lower-lid skin and provoke an excessive local collagen and inflammatory response. Published cases include tear-trough nodules that resolved with radiofrequency treatment and lower-lid granulomas that required surgery. A Singapore case report describes vision loss and strokes after PDLLA was injected into the nasolabial folds and under the eyes, a complication that occurs when product enters an artery and blocks the blood supply to the eye and brain.
  • Profhilo Bumps form at the injection points and flatten within a day or two, with swelling and occasional bruising. Worldwide post-marketing data recorded adverse events in 0.034% of an estimated 1.09 million patients, mostly swelling, redness and discomfort. The analysis was co-authored by manufacturer employees, and post-marketing data depend on voluntary reporting, so the true rate may be higher.

Can you combine Juvelook and Profhilo?

Some clinics combine the two, using Profhilo across the cheeks and jaw for hydration and Juvelook under the eyes for thickness. This division matches the areas for which each product was designed, although no study has tested the combination (Grade D).

Which lasts longer, Juvelook or Profhilo?

Juvelook is designed to last longer, because its particles continue to stimulate collagen while they are absorbed over several months, and one under-eye series reported results maintained at 6 months. Profhilo’s hydration effect is reported to last up to about 6 months after the two-session course, as the body’s own enzymes gradually break down the HA. Clinic claims that Juvelook lasts up to 24 months are not supported by study results, since the longest published follow-up is 6 months. Clinics advise maintenance about every 6 months for both.

Juvelook vs Profhilo, which to choose by concern

  • Thin skin or a mild hollow under the eyes Juvelook is the better-supported option, with a small risk of nodules. Rejuran I, a polynucleotide booster, is the lower-risk alternative and is compared in Juvelook vs Rejuran.
  • Dull, dehydrated skin, mild laxity on cheeks and jaw Profhilo is designed for this indication, because its spreading gel hydrates a wide area from five injection points per side.
  • A definite tear-trough groove Hyaluronic acid filler restores the missing volume directly, to a degree that neither booster achieves.
  • Loose under-eye skin Radiofrequency is more suitable than a booster, because heat delivered into the dermis contracts collagen and tightens lax skin. The options are compared on Sagging skin under eyes treatment.

Profhilo is also compared with Rejuran on the Profhilo vs Rejuran page.

Frequently asked questions about Juvelook and Profhilo

Is Juvelook or Profhilo better under the eyes?


Juvelook is the better-supported option under the eyes, because it has small under-eye studies and adds slight volume, whereas Profhilo has no under-eye study and its standard injection points avoid the eye area. Juvelook does, however, carry a small risk of nodules under the thin lower-lid skin.

What is the difference between Juvelook and Profhilo?


Juvelook contains PDLLA particles that stimulate new collagen and add slight volume. Profhilo is a high dose of hyaluronic acid that spreads through the skin to hydrate it and adds no volume.

How many sessions of Juvelook or Profhilo are needed?


Juvelook is usually given as three sessions four weeks apart, and Profhilo as two sessions four weeks apart. Both courses are followed by maintenance sessions about every six months.

Can Profhilo be injected under the eyes?


Some clinics inject small amounts under the eyes, but no study has tested Profhilo in this area. Lower-lid swelling is the main concern, because it has been reported even after treatment of the upper face.

Which is cheaper, Juvelook or Profhilo?


In Singapore in 2026, a Juvelook session costs S$388 to 1,200 and a Profhilo session S$700 to 1,500. A full course costs about S$1,200 to 3,600 for Juvelook and S$1,400 to 3,000 for Profhilo, so neither is consistently cheaper once the number of sessions is taken into account.

General information, not medical advice. A registered medical practitioner should be consulted before any treatment. Dark Eye Circles Singapore does not sell treatments.

Sources and price references (checked 8 October 2026)
  1. Young SM, Lau EKH. Hybrid Biostimulator and Hyaluronic Acid Injectable for Tear Trough Rejuvenation. Aesthetic Plast Surg. 2026;50(13):5337–5343. doi:10.1007/s00266-026-05817-z (PMID 42098500) — Prospective cohort, 15 women, Juvelook (PDLLA-HA 50 mg), 3 sessions; no control group; authors report VAIM speaker honoraria https://doi.org/10.1007/s00266-026-05817-z
  2. Wan J, et al. Evaluating Poly-D,L-Lactic Acid for Lower Eyelid Rejuvenation: Efficacy and Safety. J Cosmet Dermatol. 2025;24(3):e70058. doi:10.1111/jocd.70058 (PMID 40017393) — Small case series, Juvelook for tear trough, 6-month follow-up https://doi.org/10.1111/jocd.70058
  3. Park JY, et al. A Split Face Study Comparing the Effect of a PDLLA Based Product and PLLA on the Nasolabial Fold (NLF). Skin Res Technol. 2026;32(1):e70324. doi:10.1111/srt.70324 (PMID 41532837) — Randomised split-face, 33 subjects, Juvelook Volume vs PLLA, nasolabial folds, non-inferior at 24 weeks https://doi.org/10.1111/srt.70324
  4. Lee KWA, et al. Poly-d,l-lactic Acid (PDLLA) Application in Dermatology: A Literature Review. Polymers (Basel). 2024;16(18):2583. doi:10.3390/polym16182583 (PMID 39339047) — Review of PDLLA composition, mechanism and complications https://doi.org/10.3390/polym16182583
  5. Seo SB, Wan J, Yi KH. Energy-Based Device Management of Nodular Reaction Following Poly-D, L-Lactic Acid Injection for Tear Trough Rejuvenation. J Cosmet Dermatol. 2025;24(1):e16575. doi:10.1111/jocd.16575 (PMID 39283001) — Case report, nodules 3 weeks after Juvelook in the tear trough https://doi.org/10.1111/jocd.16575
  6. Garlaschi A, et al. Complex Surgical Management of PDLLA-Induced Lower Eyelid Granulomas. J Craniofac Surg. 2026. doi:10.1097/SCS.0000000000012811 (PMID 42043184) — Case report, lower-eyelid granulomas after PDLLA requiring surgery https://doi.org/10.1097/SCS.0000000000012811
  7. Tan YJ, Sugianto N, Li Y. Multifocal strokes and vision loss from PDLLA filler injections. J Stroke Cerebrovasc Dis. 2024;33(3):107556. doi:10.1016/j.jstrokecerebrovasdis.2024.107556 (PMID 38184971) — Singapore case report, PDLLA to nasolabial folds and infraorbital area https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107556
  8. Seo SB, et al. Skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary study. J Cosmet Dermatol. 2024;23(3):794–802. doi:10.1111/jocd.16085 (PMID 37969055) — 16 patients, behind-the-ear biopsy after 2 to 3 sessions https://doi.org/10.1111/jocd.16085
  9. Sparavigna A, Tenconi B. Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clin Cosmet Investig Dermatol. 2016;9:297–305. doi:10.2147/CCID.S114450 (PMID 27713647) — Open-label, 64 women, five points per side, two sessions https://doi.org/10.2147/CCID.S114450
  10. Cheng SWN, et al. Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study. Aesthetic Plast Surg. 2026;50(1):27–36. doi:10.1007/s00266-025-05188-x (PMID 40921777) — Single-centre, Singapore, 30 Chinese women; manufacturer co-authors https://doi.org/10.1007/s00266-025-05188-x
  11. Zanella G, et al. Effects of Profhilo® Tissue Bioremodeling on Skin Texture and Perioral Wrinkles: A Randomized Controlled Triple-Blind Clinical Trial. Aesthetic Plast Surg. 2026;50(11):4324–4332. doi:10.1007/s00266-026-05634-4 (PMID 41731228) — Randomised split-face vs saline, 12 women, perioral https://doi.org/10.1007/s00266-026-05634-4
  12. Saffarian Z, et al. Combined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial. Health Sci Rep. 2026;9(5):e71973. doi:10.1002/hsr2.71973 (PMID 42063688) — 20 patients; no added benefit over Botox alone https://doi.org/10.1002/hsr2.71973
  13. Dziabas DC. Use of Hyaluronic Acid Hybrid Complex to Treat Wrinkles in the Upper Third of the Face: A Case Report. Cureus. 2024;16(11):e73451. doi:10.7759/cureus.73451 (PMID 39664133) — Three patients, upper third of the face https://doi.org/10.7759/cureus.73451
  14. Tintor G, et al. Hybrid Cooperative Complexes of Low- and High-Molecular-Weight Hyaluronic Acid in Aesthetic Medicine. Pharmaceuticals (Basel). 2025;19(1):73. doi:10.3390/ph19010073 (PMID 41599673) — Review; hydration improvement lasting up to 6 months https://doi.org/10.3390/ph19010073
  15. Stellavato A, et al. Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation. PLoS One. 2016;11(10):e0163510. doi:10.1371/journal.pone.0163510 (PMID 27723763) — Laboratory study; Expression of Concern, PLoS One 2024;19(4):e0302213 https://doi.org/10.1371/journal.pone.0163510
  16. Salti G, et al. Hyaluronic Acid Hybrid Cooperative Complexes Nearing 10 Years of Use: Update on Safety Assessment Based on Post-Marketing Surveillance Data. J Cosmet Dermatol. 2025;24(7):e70197. doi:10.1111/jocd.70197 (PMID 40654100) — 371 adverse events in about 1.09 million exposed; IBSA co-authors https://doi.org/10.1111/jocd.70197
  17. Health Sciences Authority, Singapore Medical Device Register: Vaim Juvelook, DE0507634; IBSA Profhilo, DE0504719 (data.gov.sg download, April 2026 listing) https://data.gov.sg/datasets/d_e697cc1e4caec596c0e9318fdd9420a3/view
  18. Juvelook price: Bay Aesthetics Clinic — S$388 nett (JuveLook 3 ml); S$988 nett (full vial plus 2 ml HA booster) (checked 2026-10-08) https://www.bayclinic.sg/juvelook-and-lenisna-juvelook-volume-price-in-singapore/
  19. Juvelook price: Nueva Clinic — from S$688 per session (checked 2026-10-05) https://nuevaclinic.sg/treatment/juvelook/
  20. Juvelook price: V Medical Aesthetics — PDLLA Skin Booster S$1,200 nett (checked 2026-10-08) https://www.vaestheticsclinic.com.sg/juvelook/
  21. Juvelook price: Halley Medical Aesthetics — S$980 (PDLLA Skin Booster 2 ml) (checked 2026-10-05) https://www.halley.com.sg/price-list/
  22. Juvelook price: BA Clinic — S$950 per 2 ml (PDLLA skin booster) (checked 2026-10-05) https://baclinic.sg/treatments/skinbooster/
  23. Profhilo price: Bay Aesthetics Clinic — S$800 per syringe (2 ml), 5-point HA skin booster by IBSA (checked 2026-10-08) https://www.bayclinic.sg/treatment/profhilo-singapore/
  24. Profhilo price: Nexus Aesthetic — S$1,100 per 2 ml session (checked 2026-10-08) https://nexusaestheticsg.com/profhilo-treatment/
  25. Profhilo price: Kowayo Aesthetic Clinic — from S$700 per session, one 2 ml syringe (checked 2026-10-08) https://kowayo.com/face/profhilo-injectable-moisturizer-to-ageless-skin/
  26. Profhilo price: SL Aesthetic Clinic — HA 5 Point Lift from S$1,000 per session, one syringe (64 mg / 2 ml) (checked 2026-10-08) https://slclinic.com.sg/ha-5-point-lift-in-singapore/
  27. Profhilo price: Become Aesthetics — 5 Point HA Skin Lift S$1,500 per syringe (checked 2026-10-08) https://www.becomeaesthetics.com.sg/price-list/

Sagging Skin Under Eyes in Singapore: this series

Comparisons for sagging skin under eyes:

14

Dark Eye Circles Singapore

Independent reviews of eye-area concerns and treatments in Singapore. Evidence graded, 2026 prices compared, sources listed.

© 2026 Dark Eye Circles SingaporeGeneral information, not medical advice. Prices checked October 2026.