Juvelook vs Rejuran

Juvelook vs Rejuran at a glance

The table compares the two products as used under the eyes in Singapore. Evidence grades follow the scale on the About page, and prices are drawn from published clinic price lists.

Neither product’s Singapore registration names the under-eye area, so use there rests on the injector’s clinical judgement rather than on a registered indication.

Juvelook vs Rejuran for dark circles and thin under-eye skin

The choice of product depends on the type of dark circle, as explained on the Dark eye circles guide.

• Vascular or thin-skin circles Blue-purple circles, in which veins show through thin skin, respond to both products, because a thicker dermis conceals more of the underlying vessels. Rejuran I is the lower-risk choice where the skin is thin and no hollow is present.
• Brown, pigmented circles Neither product removes pigment, because neither acts on melanin. Pigment responds to laser and lightening creams, which are compared on Dark eye circles treatment in Singapore.
• Crepey lower-lid skin Both products soften fine lines by thickening the dermis. Neither tightens a fold of loose skin, which requires radiofrequency or surgery (covered on Sagging skin under eyes treatment).

What the evidence says about Juvelook and Rejuran

• EvidenceEvidence for Rejuran I and polynucleotides under the eyes, Grade C. A prospective study of 42 patients without a control group reported improved lower-lid and crow’s-feet scores up to 3 months after two sessions. An open-label study of 61 patients treated for periorbital darkness reported a shift towards milder pigmentation after three injections. In one small randomised split-face trial (27 patients enrolled) comparing a PN product with a non-cross-linked HA product around the eyes, overall improvement was similar, although the PN side scored better on roughness and pore volume. These studies tested polynucleotide products in general rather than Rejuran I in every case. A 2026 review found no direct comparative trials against filler.
• EvidenceEvidence for Juvelook under the eyes, Grade C. The main study is an uncontrolled prospective cohort of 15 women given three sessions of about 0.4 ml per eye. Investigator and patient scores improved, as did lower-lid elasticity, hydration and radiance, although both authors have received speaker fees from the manufacturer. A small Korean case series reported tear-trough improvement maintained at 6 months. The only randomised trial of a Juvelook-family product compared Juvelook Volume with poly-L-lactic acid in the nasolabial folds, not under the eyes.
• Juvelook vs Rejuran head to head, Grade D No human study has compared the two products. The only direct comparison is a 12-week study in mice, and results in mouse skin do not predict the response of the human lower lid.

Juvelook vs Rejuran side effects and nodule risk

• Rejuran I Small bumps form at the injection points for 1 to 2 days, and bruising occurs occasionally. No serious adverse events were reported in the randomised periocular trial.
• Juvelook Swelling lasts 2 to 3 days, and bruising occurs occasionally. The risk specific to Juvelook is nodules, firm lumps that can appear weeks after injection, usually where the particles have been placed too superficially in the thin lower-lid skin. Published cases include tear-trough nodules three weeks after Juvelook that resolved with radiofrequency treatment, and lower-eyelid granulomas after PDLLA injections that required two operations.
• Vascular blockage Any injected particle can block a blood vessel, and particles that enter a facial artery can be carried backwards into the arteries supplying the eye and brain. A Singapore case report describes vision loss and strokes after PDLLA was injected into the nasolabial folds and under the eyes. The complication is rare, but its risk is the reason under-eye injection should be performed by a doctor trained to recognise and treat it.

Which lasts longer, Juvelook or Rejuran?

Juvelook is designed to last longer, because its PDLLA particles are absorbed over months and continue to stimulate collagen throughout that period. Published follow-up, however, extends to 6 months at most for Juvelook and 3 months for polynucleotides. Clinic claims that Juvelook lasts up to 24 months are not supported by study results. Clinics usually advise a maintenance session every 6 months for either product.

Frequently asked questions about Juvelook and Rejuran

General information, not medical advice. A registered medical practitioner should be consulted before any treatment. Dark Eye Circles Singapore does not sell treatments.