Head-to-head comparison · 2026 Singapore prices

Juvelook vs Sculptra

/ˈdʒuːvəlʊk/ vs /ˈskʌlptrə/ Two collagen-stimulating injectables for hollows: PDLLA microspheres against poly-L-lactic acid

Dr Joy Koh, Editor-in-ChiefWritten by Dr Joy Koh, MBBS, Editor-in-Chief · Updated

Independent review: evidence graded A to D, 2026 Singapore prices from published clinic lists, sources listed at the end of the page.

Juvelook vs Sculptra: collagen stimulator comparison for hollows and sunken eyes, with evidence grade and 2026 Singapore price

Overview

Juvelook and Sculptra both stimulate collagen with polylactic acid particles, but they differ in particle design and in the areas they suit. Sculptra is poly-L-lactic acid (PLLA), made of flat, irregular particles about 50 µm across. It is approved in the United States for nasolabial folds and cheek wrinkles, and a cheek trial showed benefit to 24 months. Its labels advise against the eye area, as the US label states that periorbital use has not been studied and carries a higher reported rate of lumps, and the Australian instructions state that it should not be injected there. Juvelook is poly-D,L-lactic acid (PDLLA), made of smaller, rounder porous microspheres with a little hyaluronic acid. It is injected in thin layers under the eyes, where small studies support its use (Grade C). In the only head-to-head trial, in which 33 patients were treated in the nasolabial folds, Juvelook Volume matched Sculptra at 24 weeks. For hollow under-eyes, Juvelook is the better supported of the two, although hyaluronic acid filler remains first-line. Sculptra is suited to the temples and cheeks around a sunken eye. In Singapore in 2026, Sculptra costs about S$1,000 to 1,300 a vial and Juvelook S$388 to 688.

  • Both stimulate collagen, Sculptra as PLLA and Juvelook as PDLLA with a little hyaluronic acid
  • Sculptra labels advise against injection around the eyes
  • Under the eyes, Juvelook is Grade C, whereas Sculptra is used off-label with case reports of granulomas
  • Sculptra has the stronger evidence for cheeks and temples (Grade A for cheeks)
  • The one head-to-head trial (nasolabial folds, 33 patients) found the two comparable
  • Sculptra costs about S$1,000 to 1,300 a vial and Juvelook S$388 to 688
Introduction

Juvelook and Sculptra are both polylactic acid collagen stimulators marketed in Singapore for hollow, tired-looking faces. They behave differently under the thin skin of the lower lid, where any particle placed too superficially is more likely to show as a lump. This comparison covers how they differ, the eye-area studies and label warnings, the risks and the 2026 prices.

Juvelook vs Sculptra at a glance

Juvelook Sculptra
Material PDLLA microspheres (42.5 mg) with non-cross-linked hyaluronic acid (7.5 mg) Poly-L-lactic acid (150 mg) with carboxymethylcellulose and mannitol
Particles Round, porous, about 30 µm Flat, irregular, about 50 µm
Stronger version Juvelook Volume (Lenisna), 170 mg PDLLA with 30 mg hyaluronic acid One strength, diluted with 5 to 8 ml
US approval None Facial fat loss in HIV (2004), nasolabial folds and wrinkles (2009), cheek wrinkles (2023)
Eye area on the label Not named Not studied, with more lumps reported (US), and not to be injected (Australia)
Evidence grade, under-eye C C, off-label and advised against on the label
Evidence grade, cheeks and temples B (Juvelook Volume vs Sculptra, nasolabial folds) A for cheeks, B for temples
2026 Singapore price S$388 half vial, S$688 full vial, Juvelook Volume S$988 to 1,188 About S$1,000 to 1,300 a vial (two clinics list S$3,000)
Usual course 3 sessions, 4 weeks apart 2 to 4 sessions, at least 4 weeks apart
How long it lasts Up to 6 months in under-eye studies Up to 24 to 25 months in cheek and fold trials
Main risks Nodules if placed too superficially, rare vascular blockage Nodules and granulomas, more often around the eyes and mouth, rare vascular blockage

How Juvelook and Sculptra stimulate collagen

  • Sculptra The vial of PLLA powder is reconstituted with 5 to 8 ml of sterile water and injected into the deep dermis, the fat beneath the skin or onto the bone. As the particles break down over 18 months or longer, they provoke a controlled foreign-body reaction in which fibroblasts lay down new collagen around them. The water is absorbed within days, whereas the collagen result develops over 2 to 3 months. Because the final volume cannot be judged on the day of injection, the label warns against overcorrection. Massage of the treated area five times a day for five days is advised to spread the particles evenly.
  • Juvelook The PDLLA microspheres are smaller, rounder and porous, are absorbed faster than PLLA particles and stimulate collagen through the same foreign-body reaction. The small dose of hyaluronic acid provides some immediate hydration while the collagen response develops. Standard Juvelook is injected in thin layers under the eyes, whereas Juvelook Volume (Lenisna) is the stronger formulation for deeper volume loss.

Juvelook vs Sculptra for sunken eyes and tear troughs

  • Juvelook under the eyes, Grade C In a prospective study of 15 women, led from Singapore, three monthly sessions of about 0.4 ml per eye improved tear-trough appearance and lower-lid skin quality. The study had no control group, and both authors have received speaker fees from the manufacturer. A small Korean case series reported improvement maintained at 6 months.
  • Sculptra under the eyes, off-label In a retrospective review of 28 patients, double-diluted PLLA was placed below the lower-lid ligament, a deeper plane that keeps the particles away from the thin lid skin. Satisfaction averaged 3.4 out of 5, and one patient developed a palpable lump. Earlier reports describe visible under-eye granulomas that required surgical excision, and a 2022 review of delayed tear-trough complications linked PLLA to lumps and nodules more often than other fillers.
  • Juvelook vs Sculptra under the eyes, Grade D No study has compared the two products in the under-eye area.

Hyaluronic acid filler remains the first-line treatment for a tear-trough hollow (Grade A), because its effect is immediate and it can be dissolved with hyaluronidase if a lump or vascular problem develops. Filler options are compared on Sunken eyes treatment in Singapore.

Juvelook vs Sculptra for temples, cheeks and facial hollows

  • Head to head In a randomised split-face trial of 33 Korean patients, Juvelook Volume injected into one nasolabial fold and Sculptra into the other produced comparable improvement at 24 weeks after three sessions. One Juvelook Volume side developed moderate swelling and tenderness. The trial was funded by Juvelook’s manufacturer.
  • Sculptra on the cheeks, Grade A In the US approval trial for cheek wrinkles, 71.6% of treated patients were responders at 12 months, compared with 26.1% of untreated controls, and the effect was maintained to 24 months. A randomised trial in nasolabial folds found benefit for up to 25 months.
  • PLLA in the temples, Grade B A randomised trial of 24 patients comparing two Sculptra injection techniques rated every patient at least “improved” at 38 weeks. A larger controlled trial of 174 patients showed temple filling maintained to 12 months, but it used a different PLLA brand.

A sunken appearance around the eyes often results from hollow temples and flattened upper cheeks in addition to the tear trough, because volume lost from these areas removes the support around the orbit and deepens its shadow. The evidence for each product therefore supports a collagen stimulator for the temples and cheeks, and filler or a skin booster for the tear trough itself.

Juvelook vs Sculptra price in Singapore (2026)

Product Per vial or session Usual course Course total
Juvelook S$388 half vial, S$688 full vial (up to S$1,200 a session) 3 sessions S$1,200 to 3,600
Juvelook Volume (Lenisna) S$988 to 1,188 a vial 2 to 4 vials S$2,000 to 4,800
Sculptra (PLLA) S$988 to 1,308 a vial, S$3,000 at two clinics (vial or course not stated) 2 to 4 vials S$2,000 to 5,200 at per-vial prices

Several Singapore clinics list Sculptra only as a “PLLA collagen stimulator” without naming the brand, and a second PLLA product has been registered in Singapore since January 2026. Prices between clinics can therefore be compared only on a quote that names the product and the number of vials.

Juvelook vs Sculptra side effects and nodule risk

  • Nodules and granulomas Both products can form firm lumps under the skin. Nodules form where particles clump together, typically after superficial placement or uneven dilution, whereas granulomas are a delayed inflammatory reaction to the particles. For Sculptra, a US post-approval study recorded papules or nodules in 28% of patients, more often with larger volumes and in the marionette lines. Around the eyes, case series report granulomas appearing months after injection, some of which required surgery. For Juvelook, case reports describe tear-trough nodules that resolved with radiofrequency treatment and lower-lid granulomas that required surgical removal.
  • No dissolver Unlike hyaluronic acid filler, neither product can be dissolved with an enzyme, so persistent lumps are managed with steroid injection, energy-based treatment or surgical removal.
  • Vascular blockage Vision loss occurs when injected material enters a facial artery and travels back into the artery that supplies the eye. A 2026 review counted two cases of vision loss after PLLA and one after PDLLA with hyaluronic acid, and a separate report describes severe vision loss after periorbital PLLA. A Singapore case report describes vision loss and strokes after PDLLA was injected into the nasolabial folds and under the eyes.

Which lasts longer, Juvelook or Sculptra?

Sculptra has the longer documented effect, up to 24 to 25 months in cheek and nasolabial-fold trials. Juvelook’s under-eye studies follow patients for 6 months, and the head-to-head trial in the nasolabial folds ended at 24 weeks. Because PDLLA is absorbed faster than PLLA, a shorter duration is expected, although this has not been measured head to head.

Juvelook vs Sculptra, which to choose for each area

  • Thin skin or a mild hollow under the eyes Juvelook, or Rejuran I where the lowest lump risk is the priority, because polynucleotides contain no particles that can clump (compared on Juvelook vs Rejuran).
  • A definite tear-trough groove Hyaluronic acid filler, which fills the groove immediately and can be dissolved.
  • Hollow temples or flat upper cheeks around a sunken eye Sculptra, or Juvelook Volume.
  • Thin skin plus hydration across the face The options are compared on Juvelook vs Profhilo.

The causes of sunken eyes are explained in the Sunken-looking eyes guide.

Frequently asked questions about Juvelook and Sculptra

Can Sculptra be used under the eyes?


Some doctors inject diluted Sculptra below the under-eye ligament, but this use is off-label. The US label states that periorbital use has not been studied and is associated with more reported lumps, and the Australian instructions state that it should not be injected there.

Is Juvelook or Sculptra better for sunken eyes?


For the under-eye area itself, Juvelook has small supporting studies and is injected in thin layers, although hyaluronic acid filler remains first-line for a defined groove. Sculptra is suited to the temples and cheeks around a sunken eye.

What is the difference between Juvelook and Sculptra?


Both are polylactic acid collagen stimulators. Sculptra is poly-L-lactic acid with larger, flat particles and an effect lasting up to about two years. Juvelook is poly-D,L-lactic acid with smaller, round particles and a little hyaluronic acid.

Do Juvelook or Sculptra cause lumps?


Both can cause nodules or granulomas, more often when placed too superficially or around the eyes and mouth. Unlike hyaluronic acid filler, neither can be dissolved.

How much does Sculptra cost in Singapore?


Where clinics publish per-vial prices, Sculptra costs about S$1,000 to 1,300 a vial in 2026, and a course usually uses 2 to 4 vials. Juvelook costs S$388 for a half vial and S$688 for a full vial.

General information, not medical advice. A registered medical practitioner should be consulted before any treatment. Dark Eye Circles Singapore does not sell treatments.

Sources and price references (checked 8 October 2026)
  1. Young SM, Lau EKH. Hybrid Biostimulator and Hyaluronic Acid Injectable for Tear Trough Rejuvenation. Aesthetic Plast Surg. 2026;50(13):5337–5343. doi:10.1007/s00266-026-05817-z (PMID 42098500) — Prospective cohort, 15 women, Juvelook (PDLLA-HA 50 mg), 3 sessions; no control group; authors report VAIM speaker honoraria https://doi.org/10.1007/s00266-026-05817-z
  2. Wan J, et al. Evaluating Poly-D,L-Lactic Acid for Lower Eyelid Rejuvenation: Efficacy and Safety. J Cosmet Dermatol. 2025;24(3):e70058. doi:10.1111/jocd.70058 (PMID 40017393) — Small case series, Juvelook for tear trough, 6-month follow-up https://doi.org/10.1111/jocd.70058
  3. Park JY, et al. A Split Face Study Comparing the Effect of a PDLLA Based Product and PLLA on the Nasolabial Fold (NLF). Skin Res Technol. 2026;32(1):e70324. doi:10.1111/srt.70324 (PMID 41532837) — Randomised split-face, 33 subjects, Juvelook Volume vs PLLA, nasolabial folds, non-inferior at 24 weeks https://doi.org/10.1111/srt.70324
  4. Seo SB, Wan J, Yi KH. Energy-Based Device Management of Nodular Reaction Following Poly-D, L-Lactic Acid Injection for Tear Trough Rejuvenation. J Cosmet Dermatol. 2025;24(1):e16575. doi:10.1111/jocd.16575 (PMID 39283001) — Case report, nodules 3 weeks after Juvelook in the tear trough https://doi.org/10.1111/jocd.16575
  5. Garlaschi A, et al. Complex Surgical Management of PDLLA-Induced Lower Eyelid Granulomas. J Craniofac Surg. 2026. doi:10.1097/SCS.0000000000012811 (PMID 42043184) — Case report, lower-eyelid granulomas after PDLLA requiring surgery https://doi.org/10.1097/SCS.0000000000012811
  6. Tan YJ, Sugianto N, Li Y. Multifocal strokes and vision loss from PDLLA filler injections. J Stroke Cerebrovasc Dis. 2024;33(3):107556. doi:10.1016/j.jstrokecerebrovasdis.2024.107556 (PMID 38184971) — Singapore case report, PDLLA to nasolabial folds and infraorbital area https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107556
  7. Narins RS, et al. A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles. J Am Acad Dermatol. 2010;62(3):448–62. doi:10.1016/j.jaad.2009.07.040 (PMID 20159311) — Randomised, 233 patients, nasolabial folds; effect to 25 months https://doi.org/10.1016/j.jaad.2009.07.040
  8. Firsowicz M, et al. Injectable Poly-l-Lactic Acid for Treatment of the Infraorbital Hollowing. Dermatol Surg. 2025;51(9S):S77–S80. doi:10.1097/DSS.0000000000004791 (PMID 40864851) — Retrospective, 28 patients, infraorbital hollowing https://doi.org/10.1097/DSS.0000000000004791
  9. Trinh LN, et al. Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review. Facial Plast Surg. 2022;38(3):250–259. doi:10.1055/s-0041-1736390 (PMID 34666405) — Delayed complications of tear-trough fillers, 52 cases https://doi.org/10.1055/s-0041-1736390
  10. Apikian M, et al. Adverse reactions to polylactic acid injections in the periorbital area. J Cosmet Dermatol. 2007;6(2):95–101. doi:10.1111/j.1473-2165.2007.00303.x (PMID 17524125) — Periorbital adverse reactions to PLLA https://doi.org/10.1111/j.1473-2165.2007.00303.x
  11. Stewart DB, et al. Management of visible granulomas following periorbital injection of poly-L-lactic Acid. Ophthalmic Plast Reconstr Surg. 2007;23(4):298–301. doi:10.1097/IOP.0b013e318070d773 (PMID 17667102) — Visible periorbital granulomas after PLLA https://doi.org/10.1097/IOP.0b013e318070d773
  12. Lowe NJ, et al. Injectable poly-l-lactic acid: 3 years of aesthetic experience. Dermatol Surg. 2009;35 Suppl 1:344–9. doi:10.1111/j.1524-4725.2008.01061.x (PMID 19207324) — Retrospective survey, 221 patients; advises avoiding perioral and periorbital areas https://doi.org/10.1111/j.1524-4725.2008.01061.x
  13. Roberts SA, et al. Severe visual loss and orbital infarction following periorbital aesthetic poly-(L)-lactic acid (PLLA) injection. Ophthalmic Plast Reconstr Surg. 2012;28(3):e68–70. doi:10.1097/IOP.0b013e3182288e4d (PMID 21862947) — Visual loss after periorbital PLLA https://doi.org/10.1097/IOP.0b013e3182288e4d
  14. Young SM, et al. Visual Loss in Biostimulator Injectables: A Review of Incidence, Risk Factors, Etiology and Management Proposal. Aesthetic Plast Surg. 2026;50(5):1994–2005. doi:10.1007/s00266-025-05418-2 (PMID 41263987) — Review of visual loss after biostimulators https://doi.org/10.1007/s00266-025-05418-2
  15. Su CY, et al. Comparative Physicochemical Characterization of Polylactic Acid-Based Dermal Fillers. Polymers (Basel). 2025;18(1):84. doi:10.3390/polym18010084 (PMID 41516868) — Particle shape and size of Sculptra and Juvelook https://doi.org/10.3390/polym18010084
  16. Nikolis A, et al. A Randomized Controlled Trial Evaluating Traditional Versus Extended Techniques of Poly- l -Lactic Acid Injection for the Aesthetic Improvement of the Temporal Fossae. Dermatol Surg. 2025;51(7):702–709. doi:10.1097/DSS.0000000000004569 (PMID 39964077) — Randomised, 24 patients, temple techniques, Sculptra https://doi.org/10.1097/DSS.0000000000004569
  17. Chang G, et al. Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study. Aesthet Surg J. 2026;46(6):652–662. doi:10.1093/asj/sjag013 (PMID 41637104) — Randomised controlled, 174 patients, temples; non-Sculptra PLLA https://doi.org/10.1093/asj/sjag013
  18. Signori R, et al. Efficacy and Safety of Poly-l-Lactic Acid in Facial Aesthetics: A Systematic Review. Polymers (Basel). 2024;16(18):2564. doi:10.3390/polym16182564 (PMID 39339028) — Systematic review of 11 RCTs; low-quality evidence https://doi.org/10.3390/polym16182564
  19. US FDA. Premarket approval P030050 and supplements S002 (2009), S034 (2021), S039 (cheek wrinkles, 25 April 2023); Sculptra labelling: periorbital injection not studied https://www.accessdata.fda.gov/cdrh_docs/pdf3/P030050S039C.pdf
  20. Galderma. Sculptra Instructions for Use, Australia, August 2026 — “Do not inject … in the periorbital area” https://www.galderma.com/sites/default/files/2026-09/Sculptra%20IFU_AU_August%202026.pdf
  21. Health Sciences Authority, Singapore Medical Device Register: Q-Med Sculptra, DE0006297; Vaim Juvelook, DE0507634; Vaim Lenisna 200, DE0507633 (data.gov.sg download, April 2026 listing) https://data.gov.sg/datasets/d_e697cc1e4caec596c0e9318fdd9420a3/view
  22. Sculptra price: Bay Aesthetics Clinic — PLLA first vial (10 ml) S$988 nett; à la carte S$1,308; package of 4 vials S$1,199 per vial (checked 2026-10-08) https://www.bayclinic.sg/treatment/sculptra-singapore/
  23. Sculptra price: Sozo Aesthetic Clinic — PLLA from S$1,000, depending on vials (checked 2026-10-08) https://sozoclinic.sg/fillers/plla-collagen-stimulator/
  24. Sculptra price: Become Aesthetics — PLLA collagen biostimulator S$3,000 nett (checked 2026-10-08) https://www.becomeaesthetics.com.sg/sculptra/
  25. Sculptra price: V Aesthetics Clinic — PLLA biostimulator S$3,000 per syringe (checked 2026-10-05) https://www.vaestheticsclinic.com.sg/price-list/
  26. Juvelook Volume price: Bay Aesthetics Clinic — Lenisna 1 vial S$988 nett (checked 2026-10-08) https://www.bayclinic.sg/juvelook-and-lenisna-juvelook-volume-price-in-singapore/
  27. Juvelook Volume price: Fundamental Aesthetic Clinic — from S$1,188 nett (checked 2026-10-08) https://www.fundamentalaestheticclinic.com.sg/lenisna-juvelook-volume-singapore
  28. Juvelook price: Bay Aesthetics Clinic — S$388 nett (JuveLook 3 ml); S$988 nett (full vial plus 2 ml HA booster) (checked 2026-10-08) https://www.bayclinic.sg/juvelook-and-lenisna-juvelook-volume-price-in-singapore/
  29. Juvelook price: Nueva Clinic — from S$688 per session (checked 2026-10-05) https://nuevaclinic.sg/treatment/juvelook/
  30. Juvelook price: V Medical Aesthetics — PDLLA Skin Booster S$1,200 nett (checked 2026-10-08) https://www.vaestheticsclinic.com.sg/juvelook/
  31. Juvelook price: Halley Medical Aesthetics — S$980 (PDLLA Skin Booster 2 ml) (checked 2026-10-05) https://www.halley.com.sg/price-list/
  32. Juvelook price: BA Clinic — S$950 per 2 ml (PDLLA skin booster) (checked 2026-10-05) https://baclinic.sg/treatments/skinbooster/

Sunken Looking Eyes in Singapore: this series

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Dark Eye Circles Singapore

Independent reviews of eye-area concerns and treatments in Singapore. Evidence graded, 2026 prices compared, sources listed.

© 2026 Dark Eye Circles SingaporeGeneral information, not medical advice. Prices checked October 2026.